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Search for "protein aggregation" in Full Text gives 6 result(s) in Beilstein Journal of Organic Chemistry.
Effects of the aldehyde-derived ring substituent on the properties of two new bioinspired trimethoxybenzoylhydrazones: methyl vs nitro groups
Beilstein J. Org. Chem. 2023, 19, 1713–1727, doi:10.3762/bjoc.19.125
- first to establish the suitability of N-acylhydrazones as novel metallophores able to affect protein aggregation and/or oxidation enhanced by physiological metal–protein anomalous interactions related to Alzheimer's (AD) and Parkinson's (PD), as well as to prion diseases [27][28][29][30][31][32][33][34
Fluorinated phenylalanines: synthesis and pharmaceutical applications
Beilstein J. Org. Chem. 2020, 16, 1022–1050, doi:10.3762/bjoc.16.91
- fluorinated Phe dipeptides [84] 177c–g as racemic mixtures (Scheme 43). 5. Pharmaceutical applications of fluorinated phenylalanine derivatives Peptides and proteins containing FPhe are important tools to identify enzyme–substrate complexes, mechanisms of protein aggregation, and modifying the chemical and
Artificial Diels–Alderase based on the transmembrane protein FhuA
Beilstein J. Org. Chem. 2016, 12, 1314–1321, doi:10.3762/bjoc.12.124
- oxidized to Cu(II) by contamination with air. Cu(II) led to protein aggregation and precipitation. This was shown in an independent experiment. When one equiv of Cu(NO3)2·3H2O was added to a solution of FhuA ΔCVFtev, the protein precipitated rapidly and quantitatively. MALDI–TOF–MS analysis for the whole
Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens
Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273
- . Moreover, the concentration used has also a considerable influence on the mechanism. As examples at relatively low concentrations, the amphiphilic agents (surfactants) are membrane permeabilisers whereas at high concentrations, the penetration of these compounds in the cytoplasmic leads to protein
- aggregation [15]. It is worth mentioning that the additives may also have an effect on the biocidal activity (pH, surfactants, antioxidants, chelating agents, etc.) [16][17]. Moreover, some formulations contain mixtures of biocides in order to obtain additive or synergistic effects [18][19][20][21]. iii
Multivalent scaffolds induce galectin-3 aggregation into nanoparticles
Beilstein J. Org. Chem. 2014, 10, 1570–1577, doi:10.3762/bjoc.10.162
- ; galectin-3; glycodendrimers; multivalency; multivalent glycosylation; protein aggregation; Introduction The role of multivalency in biology is well established, and examples of this phenomenon abound [1]. The ability of multivalency to enhance weak interactions has been shown in a variety of
Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)
Beilstein J. Org. Chem. 2013, 9, 717–732, doi:10.3762/bjoc.9.82
- identification of small molecules targeting specific mechanisms of neuronal pathology, including glutamate excitotoxicity, mutant protein aggregation, endoplasmic reticulum (ER) stress, loss of trophic factors, oxidative stress, or neuroinflammation. Herein, we review recent advances in the discovery and
- , allowed the researchers to identify three distinct chemical series that were selected for optimization based on their ability to reduce both cellular toxicity and mutant SOD1 protein aggregation: arylsulfanyl pyrazolones (ASP, 10), cyclohexane-1,3-diones (CHD, 11), and pyrimidine 2,4,6-triones (PYT, 12
- TDP-43. These data suggest that Cu(II)(btsc)s, such as compound 17, may be beneficial in the treatment of ALS by modulating kinase activity and reducing protein aggregation. The removal of dysfunctional proteins and organelles from the cell can occur by the process of autophagy, whereby autophagosomes
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